Pharmacodynamics of chemotherapeutic agents such as cefotaxime and desacetyl-cefotaxime.
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منابع مشابه
Cefotaxime and desacetyl cefotaxime in human bile.
In a previous paper we reported on the determination of cefotaxime and desacetyl cefotaxime in human and rat serum after an i.v. injection of this cephalosporin (1); the concentrations of the parent compound and its metabolite in human bile were also briefly described. It has been shown that older cephalosporins with a 3~ acetoxymethyl substituent, e. g. cephalothin, are metabolised to the resp...
متن کاملDisposition of cefotaxime and desacetyl cefotaxime during continuous ambulatory peritoneal dialysis.
The disposition of cefotaxime (CTX) and desacetyl cefotaxime (DAC) was studied in eight noninfected patients on continuous ambulatory peritoneal dialysis. Each patient received a single intravenous (i.v.) infusion and an intraperitoneal (i.p.) instillation of 2 g of CTX. Multiple blood and dialysate samples were collected during the 72-h period after drug administration. The half-life, steady-s...
متن کاملComparative determination of cefotaxime and desacetyl cefotaxime in serum and bile by bioassay and high-performance liquid chromatography.
In rat serum as well as in human serum and bile after injection of cefotaxime (CTX), the parent compound and the active metabolite desacetyl cefotaxime (dCTX) have been demonstrated by quantitative analysis with high-performance liquid chromatography (HPLC). Simultaneous determination of CTX by bioassay using test organisms sensitive to both CTX and dCTX resulted in spuriously high concentratio...
متن کاملPharmacology of cefotaxime and its desacetyl metabolite in renal and hepatic disease.
The pharmacology of cefotaxime and the metabolite desacetyl cefotaxime was studied in 40 patients with various degrees of renal and hepatic failure who received 0.5 or 1 g of cefotaxime intravenously. Patients with severe renal impairment (creatinine clearance, 3 to 10 ml/min) had a cefotaxime serum half-life of 2.6 h and desacetyl cefotaxime serum half-life of 10.0 h. The equivalent figures we...
متن کاملPharmacokinetics of cefotaxime.
The pharmacokinetics of cefotaxime after intramuscular injection and intravenous infusion were determined. The mean peak serum level after the 500-mg intramuscular dose was 11.7 micrograms/ml, and it was 20.5 micrograms/ml after a 1,000-mg dose. The serum half-life was 1.2 and 1.3 h, respectively for the two doses. The apparent fractional volumes of distribution of 32 and 37 liters were not sig...
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ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1996
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.27.157